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# CITATION file created with {cffr} R package
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cff-version: 1.2.0
message: 'To cite package "phase12designs" in publications use:'
type: software
license: MIT
title: 'phase12designs: Comprehensive Tools for Running Model-Assisted Phase I/II
  Trial Simulations'
version: 0.3.1
doi: 10.32614/CRAN.package.phase12designs
abstract: 'Provides a comprehensive set of tools to simulate, evaluate, and compare
  model-assisted designs for early-phase (Phase I/II) clinical trials, including:
  - BOIN12 (Bayesian optimal interval phase 1/11 trial design; Lin et al. (2020) <https://doi.org/10.1200/PO.20.00257>),
  - BOIN-ET (Takeda, K., Taguri, M., & Morita, S. (2018) <https://doi.org/10.1002/pst.1864>),
  - EffTox (Thall, P. F., & Cook, J. D. (2004) <https://doi.org/10.1111/j.0006-341X.2004.00218.x>),
  - Ji3+3 (Joint i3+3 design; Lin, X., & Ji, Y. (2020) <https://doi.org/10.1080/10543406.2020.1818250>),
  - PRINTE (probability intervals of toxicity and efficacy design; Lin, X., & Ji,
  Y. (2021) <https://doi.org/10.1177/0962280220977009>), - STEIN (simple toxicity
  and efficacy interval design; Lin, R., & Yin, G. (2017) <https://doi.org/10.1002/sim.7428>),
  - TEPI (toxicity and efficacy probability interval design; Li, D. H., Whitmore,
  J. B., Guo, W., & Ji, Y. (2017) <https://doi.org/10.1158/1078-0432.CCR-16-1125>),
  - uTPI (utility-based toxicity Probability interval design; Shi, H., Lin, R., &
  Lin, X. (2024) <https://doi.org/10.1002/sim.8922>). Includes flexible simulation
  parameters that allow researchers to efficiently compute operating characteristics
  under various fixed and random trial scenarios and export the results.'
authors:
- family-names: Cao
  given-names: Angela
  email: cao.t.angela@gmail.com
repository: https://angela-cao.r-universe.dev
commit: 5a5f52455362b9a5ab63c728922aea43660d39f8
date-released: '2025-09-02'
contact:
- family-names: Cao
  given-names: Angela
  email: cao.t.angela@gmail.com